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apalutamide will decrease the extent or impact of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with prescription drugs which are CYP3A4 substrates can lead to decrease publicity to these medicines.The regulation of modafinil for a d